GLP-1s like Ozempic and Wegovy are transforming obesity medicine, but the story doesn’t end at weight loss. Clinical trials show that 25–40% of the weight lost on GLP-1s comes from lean mass, including muscle. Muscle is your biggest site for glucose disposal, a key regulator of metabolism, and a major factor in long-term weight maintenance. History backs this up: analysis of the Minnesota Starvation Experiment showed that the best predictor of rebound weight gain wasn’t how much fat people lost,