New technology enables the insertion of a large segment of DNA into a genome, potentially expanding gene therapy treatment ...

CRISPR is a gene editing technique with incredible potential. But the traditional CRISPR-Cas9 approach involves cutting the double helix of DNA in cells, which can have many unintended and dangerous ...

In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

A novel genome editing technique, NICER, is based on the creation of multiple nicks in single DNA strands by nickase. The method can correct heterozygous mutations using two mechanisms: multiple nicks ...

Scientists have developed a 'prime assembly' genome editing method capable of inserting DNA segments up to 11,000 base pairs, enabling replacement of entire genes and correction of up to 1,000 ...

CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes. However, this process is associated with side effects including unwanted mutations ...

A powerful new approach for the precise, flexible modification of a broad class of chemical compounds called bicyclic aza-arenes—which are commonly used to build drug molecules—has been developed. The ...

PHILADELPHIA— A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods. The approach ...

Researchers have introduced 'prime assembly,' a genome editing approach that allows insertion of large DNA segments, enabling entire gene replacements. The method avoids harmful double-strand breaks ...

Genetic editing holds promise to treat incurable diseases, but the most popular method — CRISPR — sometimes does more harm than good. A new study from University of California San Diego and Yale ...